White Willow Extract Side Effect

White willow extract is harvested from members of the willow family, which are native to parts of North America, Asia and Europe. Using white willow dates back to 400 B.C., when people chewed it to reduce pain and fever.

Drug Interactions

• White willow extract can interact with certain medications, causing dangerous side effects. Those who take non-steroidal anti-inflammatory drugs, or NSAIDs, should not use white willow extract, as it may increase the risk of stomach bleeding, according to the University of Maryland Medical Center. Blood-thinning medications also increase the risk of bleeding. White willow extract can increase the effects of methotrexate and phenytoin, causing it to reach toxic levels in the body. Taking white willow extract with beta-blocking medications can cause a decrease in drug effectiveness.

Allergic Reactions

• Allergic reactions to white willow extract can occur in those who are allergic or sensitive to aspirin. White willow extract contains salicin, a key component in aspirin. Salicylates are not recommended for pregnant women or children under 16 years old.

Pre-Existing Conditions

• Patients with pre-existing conditions such as asthma, hemophilia, gout, diabetes, gastritis and stomach ulcers should not take white willow extract because of the risk of increased bleeding in the body.

Gastrointestinal Side Effects

• White willow extract can cause gastrointestinal side effects in some people. Stomach upset, ulcers and stomach bleeding are all potential side effects of using this herb. Overdosing on white willow extract causes skin rash, nausea, vomiting, stomach irritation, ringing in the ears and kidney inflammation.